Goodfire proposes protein embedding monitors for biosecurity risks in AI agents

Goodfire Research developed sequence-aware monitors using protein language model embeddings to flag concerning biological sequences in dual-use AI agent tasks. On a custom benchmark, the monitors outperformed frontier model safeguards with fewer refusals on benign requests, and they held up better against paraphrasing and fragmentation attacks. The paraphrase results rely on in-silico estimates and do not establish whether the redesigned proteins keep biological activity, and the monitors run in milliseconds per sequence.