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AIAlphabet spinoff Isomorphic Labs is reportedly in early-stage talks to raise a new funding round at a valuation of $40 billion to $50 billion, according to Bloomberg, which did not specify the round's size. Isomorphic's flagship AI platform, IsoDDE, is designed to automate binding pocket discovery, which it says is more than 50% better than the closest competing tool, and it models antibody interactions about 2.3 times better than AlphaFold. The company earns revenue through research partnerships with Eli Lilly, Novartis and Johnson & Johnson.

AIArena's account of its continued work with The House Fund is a short acknowledgment with no product, figures, or new details. Read alongside the linked background, it sits in the context of Arena's $200M Series B at a $3.1B valuation and its Alignment Index for frontier models.

AISalesforce Ventures announced an investment in Arena's Series B round, with Arena described as a neutral platform where real users vote on anonymous model outputs across text, coding, vision, image generation, and agentic tasks. Labs and builders use its leaderboards to guide training and purchasing decisions.

AIArena announced a $200 million Series B at a $3.1 billion valuation and launched the Arena AI Alignment Index, a new measure of how AI agents behave in the real world. The main post is a thank-you from Felicis, a backer of Arena since its seed round, and the company's origins as a UC Berkeley research project.

AIApplied Digital shares fell about 2.5% after first-quarter revenue rose more than 320% year over year and beat estimates. CEO Wes Cummins said the gap between revenue growth and the share reaction should narrow over the next 12 months. He expects all contracted capacity to be online in roughly 20 to 22 months.

AIThe startup behind a popular AI model leaderboard has raised a new funding round at a $3.1 billion valuation. The main post points readers to Bloomberg's coverage of the round for further details.

AIOpenAI told investors it reached roughly $50 billion in annualized revenue at the end of September, below the $68 billion figure widely reported last month. Nvidia, Oracle, and CoreWeave shares fell on Thursday, with a person familiar saying the $68 billion figure included partner gross revenue. OpenAI is also weighing a possible funding round of around $30 billion and has not finalized a term sheet.

AISafeWorld emerged from stealth this week with $12.2 million in seed funding for its robot safety simulation platform. The software lets teams build test scenarios from past incidents, safety standards, and robot logs, then runs robots through thousands of variations with reactive human motion. SafeWorld said it supports robot arms, humanoids, and mobile robots, with customers in industrial, manufacturing, logistics, and construction.

AIAnthropic has launched the Anthropic Cyber Mission, a new effort aimed at securing critical infrastructure and open-source software. The post links to a company news page with further details.

AIManus, the developer of the Manus AI agent, has raised more than $500 million led by Boyu Capital, with Tencent also investing. Bloomberg had reported a $4 billion valuation, roughly double Meta's reported offer last December, which Chinese regulators blocked in April. The funding comes days after Manus 2.0 added a new harness, Cloud Computer, and Cue, which lets agents use email accounts and digital wallets.

AICoreWeave is positioning its AI cloud around an open development loop, connecting training, inference and evaluation through its newly announced CoreWeave Forge platform. Chief marketing officer Jean English said the company wants production learnings to improve models and agents and that the loop should work across different models, frameworks and clouds. She argued that competitive differentiation extends beyond GPUs to partner tooling, infrastructure and APIs.

AIThe California State Athletic Commission sent a cease-and-desist letter to startup Rek over a September 18 match pitting a human against a humanoid robot piloted remotely. The letter, posted by Rek CEO Cix Liv, calls the fight unsanctioned and demands that Rek stop promoting human-involved contests in California without approval. Rek's next planned match on Friday will feature two weaponized robots fighting each other.

AIThree OpenAI safety researchers, Jasmine Wang, Tomek Korbak, and Mikita Balesni, were fired after OpenAI said they mishandled sensitive information by sharing it with an outside AI safety organization. In an open letter, they deny the claims, argue the dismissals will deter employees from raising safety concerns, and call on OpenAI to keep its public commitments on third-party safety auditing. OpenAI says the firings followed an investigation into a pattern of misconduct and denies they were retaliation for safety concerns.

AIDecagon Labs has launched Chord, a new speech model, and Modal says it was trained and served on its platform. Modal reports low time-to-first-audio even during large swings in concurrency. Decagon says post-training preserved pace and voice naturalness and raised resolution rates in every deployment.

AIA 16-year-old hiker, Bryce Vincent Gowryluk, was rescued in British Columbia after route directions from the AI chatbot Claude led him to the base of the Widowmaker Arete, a climbing wall requiring ropes and cams. Rescuers said he was "far off" his intended route to Crown Mountain, and North Shore Rescue had to hoist two members down to lift him out. Search manager Paul Markey warned hikers not to rely blindly on AI for route planning.

AILettering artist Jessica Hische designed the M logo for Meta's new AI assistant Muse, a two-day freelance sprint she says paid about $12,500. She said she took the job to cover payroll for her Oakland shops, and the decision drew heavy criticism from fellow designers on Threads.

AIThe Alzheimer's Translation Challenge, led by Primamente and AlzData with NVIDIA, Hugging Face, Nebius, Talisman Therapeutics, Ultima Genomics, Cellanome, Prime Intellect, and Boltz, is now open for registration. The competition starts in spring 2027, according to the post.

AIParticipants will use a dataset to build AI models, evaluated through a series of evals ranging from general benchmarks to more complex tasks. Top teams will be shortlisted and have their experimental hypotheses tested in Prima Mente's wet lab.

AIFired OpenAI safety researchers published the full letter they sent to the company's board. The author, quoted in a linked post, believes they were dismissed for prioritizing safety over OpenAI's near-term corporate interests.

AIAnthropic has updated Claude's usage policy for the first time in over a year, banning sustained and needless abusive or cruel behavior toward Claude. The company says ordinary frustration, pushback, dark creative themes, and model testing are not covered, and that the rule applies only in extreme cases. Violations can lead to warnings, throttling, restriction, suspension, or termination of access.

AIMicrosoft will replace per-user OneDrive allowances on Microsoft 365 Family and Premium plans with a shared 2 TB storage pool, down from 6 TB across six accounts. Heavy users could face bills that double or triple, since each extra 1 TB adds $10 a month, while family members will be able to share a single AI usage allowance. New and upgraded subscriptions get shared storage starting Oct. 8, 2026, and existing subscribers move at their first renewal on or after May 2, 2027.

AIThe U.S. Department of Labor said it suspended Microsoft and Adobe from its Permanent Labor Certification program, citing multiple active federal investigations. Labor Secretary Keith Sonderling also said no new applications will be accepted for Cognizant, Infosys, Capgemini, Tata, Wipro and HCL. Microsoft said the vast majority of its U.S. employees are Americans and that 80% of its roughly 6,000 H-1B petitions last fiscal year were to extend or change the status of existing employees.

AIArena has secured a $200M Series B, with Lightspeed doubling down on its investment. The company is also launching the Alignment Index, which measures how closely AI behavior aligns with human values in real-world settings. Arena reports annualized revenue above $100M since its Series A, with millions of people helping evaluate frontier models through real-world use.

AIOpenAI is rolling out GPT-6.1 Sol Ultrafast, which generates tokens up to 8x faster than Sol Standard. On the API it costs $12 per 1M input tokens and $60 per 1M output tokens, and the main post says it is just 1.2x the cost of Astra.

AIArena, the crowdsourced AI model leaderboard that started as a UC Berkeley research project, raised a $200 million Series B at a $3.1 billion valuation, led by Lightspeed Venture Partners and Khosla Ventures. The company said it reached $100 million in annualized run-rate revenue in June, up from $30 million when it raised its $150 million Series A in January at a $1.7 billion post-money valuation.

AIOpenAI has reportedly told investors its annualized revenue is approaching $50 billion, about $20 billion below a previously reported $70 billion figure. The Financial Times reports the earlier number came from investor attempts to compare OpenAI with Anthropic, which counts cloud partners' sales differently. OpenAI's IPO has reportedly been pushed to early 2027.

AIThe Association of Historical Mathematicians (AHM) has called for a boycott of OpenAI after the company released more than 700 AI-generated proof files at once. Fields Medalist Terence Tao, who chairs the group, argues that AI solving open problems autonomously reduces seminars, collaborations, and fertile research directions, and that the field should shift its measure of progress toward explanation and community-building.

Why it matters: The article links the AHM boycott call to Tao's argument that AI-driven proof volume is changing how mathematicians measure progress and whether solutions remain useful.

AITrump disclosed more than 500 securities transactions in August, including a purchase of up to $25 million in Meta stock and up to $5 million in SpaceX senior unsecured notes. The filing, which reports trades in value ranges, shows total activity of roughly $74.3 million to $273.3 million according to a CNBC analysis. The SpaceX notes were bought two days before Trump signed a national space transportation policy, and the White House says the portfolio is independently managed.

AIAnthropic updated its usage policy on October 8, 2026, codifying bans on election interference, weapons software, and surveillance. It also expressly forbids prolonged verbal abuse of Claude, applying only to extreme cases of repeated cruelty with no discernible purpose.

AISpaceXAI has joined the Omacom Foundation as a Founding Corporate Patron, providing $1,500,000 in Grok tokens for Omarchy's maintenance and development. The main post says the company is glad to support the Omarchy team.

AIOpenAI released hundreds of claimed solutions to hard math problems but did not fully meet guidelines from the Advisory Group on Mathematics and Artificial Intelligence. Only 10 of 719 manuscripts included chain-of-thought releases, and just 42% of proofs were formalized. A Cambridge and King's College paper found discrepancies between a natural language proof and its Lean code for a Navier-Stokes-derived problem.

AIAutomation Anywhere Inc. announced an agreement to acquire Boost.ai Inc., a conversational voice AI company, from Nordic Capital, to extend its autonomous enterprise platform into customer experience. Boost.ai supports more than 36 languages, serves hundreds of customers in regulated industries and Europe, and maintains more than 650 deployments and about 600 live AI agents. The deal follows Automation Anywhere's late 2025 acquisition of Aisera Inc.

AIUSA Today Co. and several local newspapers it owns sued OpenAI, alleging the company copied "hundreds of thousands" of articles to train its AI models without permission. The publisher seeks damages of more than $250 million, arguing the unauthorized use has caused real and continuing harm. OpenAI did not immediately respond to The Verge's request for comment.